Isomerase were approached by a biotech company looking to generate analogues of a known natural product peptide/polyketide, produced by a filamentous streptomycete bacteria.

• Solution: Strain improvement, USP and DSP development alongside bioengineering

Strain improvement was carried out via rational and classical approaches, alongside fermentation optimisation and DSP development. Titres (which were initially <0.01mg/L) reached the target required by the partner (>1g/L). Bioengineering on the strain was carried out to allow production of a range of related products, by feeding different small synthetic precursors. These were fermented, isolated and supplied for further activity and property testing.

 novel analogues of a mixed peptide

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